Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8242382 | International Journal of Radiation Oncology*Biology*Physics | 2007 | 10 Pages |
Abstract
Conclusion: It appears that EGFR expression is not correlated with cytotoxic effects exerted by cetuximab. Combination treatment with TMZ, cetuximab and radiation resulted in independent toxicity in three out of five cell lines evaluated, the antagonistic effect of the TMZ/cetuximab combination in two cell lines could indicate that TMZ preferentially kills cetuximab-resistant cells, suggesting for some cross-talk between toxicity mechanisms. Expression of EGFR was no surrogate marker for responsiveness to cetuximab, alone or in combination with RT and TMZ.
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Authors
Stephanie E. M.D., Daniela M.D., Wilfried M.D., Christel Ph.D., Jürgen M.D., Ph.D., Klaus-Josef Ph.D.,