Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8242707 | International Journal of Radiation Oncology*Biology*Physics | 2007 | 9 Pages |
Abstract
Conclusions: Early changes in lung perfusion, among other factors initiate, the development of hypoxia and chronic oxidative stress after irradiation. Tissue hypoxia is associated with a significant increase in the activation of macrophages and their continuous production of reactive oxygen species, stimulating the production of fibrogenic and angiogenic cytokines, and maintaining the development of chronic radiation-induced lung injury.
Related Topics
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Authors
Katharina M.D., Larisa M.D., Liguang M.D., Ph.D., Zahid M.D., Isabel L. B.S., Bradley B.S.E., John M.D., Ph.D., W. Michael Ph.D., Zeljko M.D., Ph.D.,