Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8244002 | International Journal of Radiation Oncology*Biology*Physics | 2006 | 10 Pages |
Abstract
Viral oncolytic therapy has been pursued with renewed interest as the molecular basis of carcinogenesis and viral replication has been elucidated. Genetically engineered, attenuated viruses have been rationally constructed to achieve a therapeutic index in tumor cells compared with surrounding normal tissue. Many of these attenuated mutant viruses have entered clinical trials. Here we review the preclinical literature demonstrating the interaction of oncolytic viruses with ionizing radiation and provides a basis for future clinical trials.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Sunil J. M.D., James J. M.D., Bernard Sc.D., Ralph R. M.D.,