Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8247836 | International Journal of Radiation Oncology*Biology*Physics | 2006 | 9 Pages |
Abstract
Conclusion: These results emphasize anti-TGF-β1 treatment to reduce radiation-induced fibrosis by decreasing α1(I)-procollagen synthesis in vivo. α1(I)-procollagen and α2(I)-procollagen might be differentially regulated by anti-TGF-β1 treatment. Increased TGF-β signaling in irradiated skin fibroblasts seemed to be reversible, as shown by a reduction in PAI-1 expression after anti-TGF-β1 treatment.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Stefan M.D., D.M.D., Ph.D., Jürgen M.D., Michael M.D., D.M.D., Franz Ph.D., Ivan M.D., Gerhard G. M.D., Ph.D., Kerstin M.D., Ph.D., Falk M.D.,