Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8247947 | Life Sciences in Space Research | 2018 | 18 Pages |
Abstract
The cultures clearly exhibited the capacity to repair induced DNA damage almost completely within 24Â h, even at doses of 7Â Gy, and almost completely recovered from radiation-induced changes in proliferative behavior. Interestingly, no significant effects on apoptosis could be detected. Especially the functionality of primary cardiac cells exhibited a surprisingly high robustness against heavy ion radiation, even at doses of up to 7Â Gy. In contrast to our previous study with X-rays the beat rate remained more or less unaffected after heavy ion radiation, independently of beam quality. The only change we could observe was an increase of the field action potential duration of up to 30% after titanium irradiation, diminishing within the following three days. This potentially pathological observation may be an indication that heavy ion irradiation at high doses could bear a long-term risk for cardiovascular disease induction.
Related Topics
Physical Sciences and Engineering
Earth and Planetary Sciences
Space and Planetary Science
Authors
Anja Heselich, Johannes L. FrieÃ, Sylvia Ritter, Naja P. Benz, Paul G. Layer, Christiane Thielemann,