Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8257258 | Ageing Research Reviews | 2015 | 9 Pages |
Abstract
To date, most studies of Shc family of signaling adaptor proteins have been focused on the near-ubiquitously expressed ShcA, indicating its relevance to age-related diseases and longevity. Although the role of the neuronal ShcC protein is much less investigated, accumulated evidence suggests its importance for neuroprotection against such aging-associated conditions as brain ischemia and oxidative stress. Here, we summarize more than decade of studies on the ShcC expression and function in normal brain, age-related brain pathologies and immune disorders with a focus on the interactions of ShcC with signaling proteins/pathways, and the possible implications of these interactions for changes associated with aging.
Keywords
GluRAβPPIRASAPPSHCNGFNMDAGDNFN-methyl-d-aspartateEGFRARDSPTBCrkSH2GRB2CH1NGFRRICSPI3KEGFLPSBCRBDNFERK1/2MAPKRNA interferenceRNAiROSRTKsSrc homology 2 domainALKAktAxlBrain ischemiaBeta-amyloidAlzheimer's diseaseAge-related diseasesParkinson's diseaseProtein–protein interactionlong-term potentiationLTPBrain tumorsRETphosphotyrosine-binding domainRearranged during transfectionCNSAgingcentral nervous systemSignalingepidermal growth factornerve growth factorphosphatidylinositide 3-kinaseFynlipopolysaccharideImmunityprotein kinase B (PKB)mitogen-activated protein kinasegrowth factor receptor-bound protein 2Cellular senescenceextracellular signal-regulated kinases 1 and 2Gab1Reactive oxygen speciesReceptor Tyrosine Kinasereceptor tyrosine kinasesB cell receptorEpidermal growth factor receptornerve growth factor receptor
Related Topics
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Orli Sagi, Arie Budovsky, Marina Wolfson, Vadim E. Fraifeld,