Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells

Article ID	Journal	Published Year	Pages	File Type
8258384	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2018	46 Pages	PDF

Abstract

In conclusion, Nogo-B was shown to play an important negative role in apoptotic signaling through its interaction with c-FLIP in colorectal cancer cells, and may thus become a novel therapeutic target for colorectal cancer.

Keywords

Nogo-B si-RNA c-FLIP STS GAPDH RPMI DMSO Small interfering RNA staurosporine Immunofluorescence Immunohistochemistry IHC Immunoprecipitation Apoptosis Dimethyl sulfoxide Colorectal cancer endoplasmic reticulum Fas Ligand FasL Roswell Park Memorial Institute medium protein kinase RNA-like endoplasmic reticulum kinase PERK CRC glyceraldehyde-3-phosphate dehydrogenase

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Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells

Authors

Nao Kawaguchi, Keitaro Tashiro, Kohei Taniguchi, Masaru Kawai, Keitaro Tanaka, Junji Okuda, Michihiro Hayashi, Kazuhisa Uchiyama,