Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8258416 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 14 Pages |
Abstract
In this report we present the Virtual Melanoma Cell, an online tool developed to facilitate the mining and interpretation of high-throughput data on melanoma by biomedical researches. The platform is based on a comprehensive, manually generated and expert-validated regulatory map composed of signaling pathways important in malignant melanoma. The Virtual Melanoma Cell is a tool designed to accept, visualize and analyze user-generated datasets. It is available at: https://www.vcells.net/melanoma. To illustrate the utilization of the web platform and the regulatory map, we have analyzed a large publicly available dataset accounting for anti-PD1 immunotherapy treatment of malignant melanoma patients.
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Authors
Florian S. Dreyer, Martina Cantone, Martin Eberhardt, Tanushree Jaitly, Lisa Walter, Jürgen Wittmann, Shailendra K. Gupta, Faiz M. Khan, Olaf Wolkenhauer, Brigitte M. Pützer, Hans-Martin Jäck, Lucie Heinzerling, Julio Vera,