Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8258430 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 54 Pages |
Abstract
This study demonstrated that benzbromarone aggravated hepatic steatosis in obese individuals, which could subsequently contribute to hepatic cell injury, suggesting a novel toxicological mechanism in benzbromarone-induced hepatotoxicity.
Keywords
NAFLDFFAsDIONEFAHFDBBRALTdiet induced obeseBenzbromaronePPARsASTAspartate aminotransferaseAlanine aminotransferaseHepatic steatosisER stressEndoplasmic reticulum stressFree fatty acidsNonalcoholic fatty liver diseasetriglycerideHigh fat dietnormal dietHepatotoxicitybody mass indexBMIObesityHematoxylin and EosinPeroxisome proliferator-activated receptors
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Peng Sun, Jing-Jie Zhu, Ting Wang, Qi Huang, Yu-Ren Zhou, Bang-Wei Yu, Hua-Liang Jiang, He-Yao Wang,