| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8258430 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 54 Pages |
Abstract
This study demonstrated that benzbromarone aggravated hepatic steatosis in obese individuals, which could subsequently contribute to hepatic cell injury, suggesting a novel toxicological mechanism in benzbromarone-induced hepatotoxicity.
Keywords
NAFLDFFAsDIONEFAHFDBBRALTdiet induced obeseBenzbromaronePPARsASTAspartate aminotransferaseAlanine aminotransferaseHepatic steatosisER stressEndoplasmic reticulum stressFree fatty acidsNonalcoholic fatty liver diseasetriglycerideHigh fat dietnormal dietHepatotoxicitybody mass indexBMIObesityHematoxylin and EosinPeroxisome proliferator-activated receptors
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Authors
Peng Sun, Jing-Jie Zhu, Ting Wang, Qi Huang, Yu-Ren Zhou, Bang-Wei Yu, Hua-Liang Jiang, He-Yao Wang,