Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8258456 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 42 Pages |
Abstract
Atherosclerosis, a chronic inflammatory disorder of medium and large arteries and an underlying cause of cardiovascular disease (CVD), is responsible for a third of all global deaths. Current treatments for CVD, such as optimized statin therapy, are associated with considerable residual risk and several side effects in some patients. The outcome of research on the identification of alternative pharmaceutical agents for the treatment of CVD has been relatively disappointing with many promising leads failing at the clinical level. Nutraceuticals, products from food sources with health benefits beyond their nutritional value, represent promising agents in the prevention of CVD or as an add-on therapy with current treatments. This review will highlight the potential of several nutraceuticals, including polyunsaturated fatty acids, flavonoids and other polyphenols, as anti-CVD therapies based on clinical and pre-clinical mechanism-based studies.
Keywords
Japan EPA Lipid Intervention StudyDGLAVLDLPCSK9TMAOPWVFMDoxLDLCHDECMGLALDL-CLDLRCoQ10CANTOSKIHDHDLIMPROVE-ITGPROMEGAGISSIEPAG-protein-coupled receptorhigh-density lipoproteinOxidized LDLAtherosclerosisMyocardial infarctionapoapolipoproteinStrengthEicosapentaenoic acidPolyunsaturated fatty acidsPolyunsaturated fatty acidPUFAgamma-linolenic acidOriginFlow-mediated dilationinterleukincoronary heart diseasecardiovascular diseaseESRD یا end stage renal diseasetriacylglycerolTrimethylamine-n-oxideJELISMarinedihomo-gamma-linolenic acidCVDPulse wave velocityFourierAnchorvery low-density lipoproteinLow-density lipoproteinLDLExtracellular matrixMagmaend stage renal diseaseNutraceuticalsNitric oxideASAPC-reactive proteinCRPProprotein convertase subtilisin/kexin type 9PolyphenolsPREDIMEDCocoaLDL-cholesterolCoenzyme Q10LDL receptor
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Authors
Joe W.E. Moss, Jessica O. Williams, Dipak P. Ramji,