Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8258494 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 12 Pages |
Abstract
Cholangiocytes are epithelial cells that line the intra- and extrahepatic biliary tree. They serve predominantly to mediate the content of luminal biliary fluid, which is controlled via numerous signaling pathways influenced by endogenous (e.g., bile acids, nucleotides, hormones, neurotransmitters) and exogenous (e.g., microbes/microbial products, drugs etc.) molecules. When injured, cholangiocytes undergo apoptosis/lysis, repair and proliferation. They also become senescent, a form of cell cycle arrest, which may prevent propagation of injury and/or malignant transformation. Senescent cholangiocytes can undergo further transformation to a senescence-associated secretory phenotype (SASP), where they begin secreting pro-inflammatory and pro-fibrotic signals that may contribute to disease initiation and progression. These and other concepts related to cholangiocyte pathobiology will be reviewed herein. This article is part of a Special Issue entitled: Cholangiocytes in Health and Disease edited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen.
Keywords
EGFRNF-κBPI3KHSCLPSmRNANRASCIScGMPBcl-2PSCVIPBDLAE2PRBpKaADPNGFIP3TRPV4CFTRPKCMrp2AQPIP3RTGFIBATEpacSSTR2BSEPSK2PBCCholangiocytesNLRP3VEGFRADPKDSGLT1NHENtcpFOXA2SMADPCKSASPH3K4me3GLP1Cdc25aGRB2CDKNcholangiopathiesETS1Friend of GATACCK-BFog2TNFForkhead box A2cell division cycle 25Anuclear factor kappa-light-chain enhancer of activated B cellsneuroblastoma RAS viral oncogene homologhistone 3 lysine 4 trimethylationα-CGRPcAMPprimary biliary cholangitisERK1/2Inositol 1,4,5-triphosphateMAPKNa+/H+ exchangerAdenosine TriphosphateATPadenosine diphosphateCyclic adenosine monophosphateAsbtangiopoietinaquaporinmicro-ribonucleic acidgamma-aminobutyric acidAnginterferonIFNinterleukinautosomal dominant polycystic kidney diseasetransforming growth factorProliferationApoptosismessenger ribonucleic acidcystic fibrosis transmembrane conductance regulatorHepatic stellate cellBileVascular endothelial growth factornerve growth factortumor necrosis factorphosphatase and tensin homologphosphoinositide 3-kinaseSenescence-associated secretory phenotypeTRAILB-cell lymphoma 2lipopolysaccharideanion exchanger 2Hedgehog signaling pathwayCyclin-dependent kinase inhibitorscyclic guanine monophosphateMiRNANeurogenin-3histamine H3 receptorretinoblastoma proteinexchange protein activated by cAMPMultidrug resistance protein 2protein kinase AProtein kinase Cmitogen-activated protein kinasegrowth factor receptor-bound proteinorganic anion-transporting polypeptidePolycystinglucagon-like peptide 1Senescencebile duct ligationPtenPrimary sclerosing cholangitispolycystic kidneyextracellular signal-regulated kinaseGABAInositol 1,4,5-triphosphate receptorEstrogen receptorvascular endothelial growth factor receptorEpidermal growth factor receptor
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Authors
Angela C. Cheung, Maria J. Lorenzo Pisarello, Nicholas F. LaRusso,