| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8258514 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 10 Pages |
Abstract
Activation of FXR inhibits, whereas TGR5 activation may promote, CCA progression by regulating proliferation, migration and mitochondrial energy metabolism. Modulation of FXR or TGR5 activities may represent potential therapeutic strategies for CCA.
Keywords
G protein-coupled bile acid receptor 1FXRPBCOCATGR5OCRPSCCCAGAPDHNHCqPCRFBSTLCADMEMPCNAprimary biliary cholangitisfarnesoid X receptorDulbecco's modified Eagle's mediumP/SProliferating Cell Nuclear AntigenNon-alcoholic steatohepatitisobeticholic acidTaurolithocholic acidBile acidBile acidsMRIMagnetic resonance imagingstandard error of the meanTherapyfetal bovine serumSEMOxygen consumption rateNash quantitative polymerase chain reactionPenicillin/streptomycinPrimary sclerosing cholangitisCholangiocarcinomaglyceraldehyde-3-phosphate dehydrogenase
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Authors
Erice O., Labiano I., Arbelaiz A., Santos-Laso A., Munoz-Garrido P., Jimenez-Agüero R., Olaizola P., Caro-Maldonado A., MartÃn-MartÃn N., Carracedo A., Lozano E., Marin J.J., O'Rourke C.J., Andersen J.B., Llop J., Gómez-Vallejo V., Padro D.,