| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8258517 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 40 Pages |
Abstract
This review aims to summarize (i) the present knowledge on clinical and morphological characteristics of cholemic nephropathy, (ii) available preclinical models, (iii) potential pathomechanisms especially the potential role of bile acids, and (iv) future diagnostic and therapeutic strategies for cholemic nephropathy. This article is part of a Special Issue entitled: Cholangiocytes in Health and Disease edited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen.
Keywords
CBDLNGALGFRSIRSKDIGOPBCLFABPFXRNOS2IL-18TLR-4norUDCAKIM-1uNGALiNOSPSCnicotinamide adenine dinucleotide phosphate hydrogenPAMPsNADPHAKILPSprimary biliary cholangitisfarnesoid X receptoracute kidney injuryBile acidspathogen-associated molecular patternsInterleukin 18chronic kidney diseaseinducible nitric oxide synthaseSystemic inflammatory response syndromeliver cirrhosisLipopolysaccharidesCKDGlomerular filtration ratePASnitric oxide synthase 2common bile duct ligationPrimary sclerosing cholangitisToll-like receptor 4
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Authors
Elisabeth Krones, Marion J. Pollheimer, Alexander R. Rosenkranz, Peter Fickert,