Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8258625 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 32 Pages |
Abstract
Molecular mechanisms for macrophage immune responses modulated by SIRT1 during sepsis remain unclear. Here, we show that SIRT1 expression is down-regulated in macrophages from mouse sepsis model or LPS stimulation. SIRT1 expression in macrophages correlates with low levels of a long noncoding RNA (lncRNA)-NONMMUT003701 [named as lncRNA-CCL2]. SIRT1 inhibits lncRNA-CCL2 expression via sustaining a repressive chromatin state in the lncRNA-CCL2 locus. The inflammation cytokines expression is downregulated by knockdown of lncRNA-CCL2. Such inhibition can be reversed partly by decreased SIRT1 activity. Thus, this work uncovers previously unidentified mechanisms in which SIRT1 associates with lncRNA and lncRNA regulates macrophage inflammatory response.
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Authors
Yanhui Jia, Zhenzhen Li, Weixia Cai, Dan Xiao, Shichao Han, Fu Han, Xiaozhi Bai, Kejia Wang, Yang Liu, Xiaoqiang Li, Hao Guan, Dahai Hu,