| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8258643 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 22 Pages |
Abstract
In conclusion, either ECM accumulation-associated or pharmacologically induced silencing of WNT-levels allowed for a more anabolic reaction of chondrocytes to physiological loading. This is consistent with the role of proteoglycans in sequestering WNT-ligands in the ECM, thus reducing WNT-activity and also provides a novel explanation of why low WNT-activity in cartilage protects from OA-development in mechanically overstressed cartilage.
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Authors
Heiko Praxenthaler, Elisabeth Krämer, Melanie Weisser, Nicole Hecht, Jennifer Fischer, Tobias Grossner, Wiltrud Richter,