| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8258712 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 10 Pages |
Abstract
Our findings indicate that brain APOE3 expression is associated with a potent inhibition of visceral WAT mitochondrial oxidative phosphorylation, leading to significantly reduced substrate oxidation, increased fat accumulation and obesity. In contrast, peripherally expressed APOE3 is associated with a notable shift of substrate oxidation towards non-shivering thermogenesis in visceral WAT mitochondria, leading to resistance to obesity.
Keywords
GFAPCOX4APOE2Rps18DGAT-1ApoA2APOC1UCFApoE3APOC3apoA1LRP1CytCBCSFBAPOE4BATHDLRT-PCRLDLRALTS.E.M.ApoE−/−Ucp1ASTalanine transaminaseApoebrown adipose tissueBriteaspartate transaminasestandard error of the meanCNSBBBcentral nervous systemperipheral nervous systemFasnUltracentrifugationhigh density lipoproteinblood-cerebrospinal fluid barrierBlood-brain barrierPPAR-gammaplaque forming unitsreal-time polymerase chain reactionpfuPNS
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Authors
Aikaterini Hatziri, Christina Kalogeropoulou, Eva Xepapadaki, Eleni Birli, Eleni A. Karavia, Eugenia Papakosta, Serafoula Filou, Caterina Constantinou, Kyriakos E. Kypreos,