Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8258781 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 33 Pages |
Abstract
Our results demonstrated that metformin activated SIRT1 and AMPK, prevented hyperglycemia-induced reduction of SIRT1 protein levels, ameliorated glucose uptake into podocytes, and decreased glomerular filtration barrier permeability. Furthermore, metformin activated AMPK in a SIRT1-independent manner, as the increase in AMPK phosphorylation after metformin treatment was not affected by SIRT1 downregulation. Therefore, the potentiating effect of metformin on insulin-resistant podocytes seemed to be dependent on AMPK, as well as SIRT1 activity, establishing multilateral effects of metformin action.
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Authors
Dorota Rogacka, Irena Audzeyenka, MichaÅ RychÅowski, Patrycja Rachubik, Maria Szrejder, Stefan Angielski, Agnieszka Piwkowska,