Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8259099 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2016 | 11 Pages |
Abstract
Based on our data, we propose a model depicting a role of MALAT1 in the regulation of arsenite-enhanced glycolysis. In L-02 cells, MALAT1 is induced by arsenite. With arsenite exposure, MALAT1 blocks HIF-1α hydroxylation and then disrupts the HIF-1α-VHL interaction, stabilizes HIF-1α and increases expression of glycolytic enzymes, such as HK-2, Eno-1, and Glut-4 thereby promoting glycolysis; HIF-1α enhances arsenite-induced glycolysis may through p53 and NF-κB. In summary, in L-02 cells exposed to arsenite, MALAT1 is involved in the Warburg effect.79
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Authors
Fei Luo, Xinlu Liu, Min Ling, Lu Lu, Le Shi, Xiaolin Lu, Jun Li, Aihua Zhang, Qizhan Liu,