Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8259215 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2016 | 37 Pages |
Abstract
Our results suggest that a C21-induced VEGF upregulation may be crucial after an ischemic neuronal insult in both of our experimental approaches. This upregulation was mediated by a mechanism dependent of Akt/mTOR signaling pathway, since mTOR inhibition abolished the VEGF upregulation induced by C21. Considering that VEGF is involved in regenerative processes, we propose that AT2R activation could be used as a potential pharmacological strategy after ischemic stroke.
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Authors
Laura Mateos, Maria Jose Perez-Alvarez, Francisco Wandosell,