Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8259414 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2016 | 99 Pages |
Abstract
Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of the population. Its multi-factorial etiology includes oxidative stress and the overproduction of reactive oxygen species, which regulate intracellular signaling processes, chondrocyte senescence and apoptosis, extracellular matrix synthesis and degradation along with synovial inflammation and dysfunction of the subchondral bone. As disease-modifying drugs for osteoarthritis are rare, targeting the complex oxidative stress signaling pathways would offer a valuable perspective for exploration of potential therapeutic strategies in the treatment of this devastating disease.
Keywords
ATF/CREOXPHOSGPXNADPHCOX-2CATBcl-2ECMNOSiNOSPGE2HNE4-hydroxynonenalCASPADAMTSATF-2Jnk PeroxynitriteCREB-1IL-6MDAONOOHXRCC5PI3KNF-κBOCl−c-Jun N-terminal kinaseMitochondrial DNAMAPKNO2−NO3−O2−OH−ONOO−ROS superoxide anionOsteoarthritisPeroxynitrous acidinterleukin-6Baxa disintegrin and metalloproteinase with thrombospondin motifsOxidative stresstumor necrosis factor alphamtDNASODinducible nitric oxide synthaseSuperoxide dismutasecyclooxygenase 2CartilageVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)TNF-αFoxOphosphatidylinositol-3-kinaseOxidative phosphorylationactivating transcription factor 2B-cell lymphoma 2Extracellular matrixmalondialdehydeNitric oxidenitric oxide synthasenicotinamide adenine dinucleotide phosphateBcl-2-associated X proteinmitogen-activated protein kinaseProstaglandin E2CatalasecaspaseCollagenChondrocytescolGlutathione peroxidiseReactive oxygen species
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Panagiotis Lepetsos, Athanasios G. Papavassiliou,