| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8259484 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2016 | 34 Pages |
Abstract
These results indicate that mice lacking Vnn1 have deficiencies in compensatory repair and immune responses following toxic APAP exposure and that these mechanisms may contribute to the enhanced hepatotoxicity seen.
Keywords
TNFMRPAPAPCCR2NAPQIN-acetyl-p-benzoquinone imineNQO1TGFβ1GCLCCCl4ConAALTiNOSDTNBGSSGalanine aminotrasferaseNACGSHUGTCYP450PPARACFBConcanavalin APCNA3′-phosphoadenosine 5′-phosphosulfate5,5′-dithiobis(2-nitrobenzoic acid)BSAMPOIfngNAD(P)H:quinone oxidoreductase 1PAPsPeroxisome proliferatorsUDP-glucuronosyltransferasebovine serum albuminperoxisome proliferator-activated receptor alphaProliferating Cell Nuclear AntigenAcetaminopheninterleukintransforming growth factor beta 1cluster of differentiationinducible nitric oxide synthaseCytochrome P450Cysteaminetumor necrosis factormyeloperoxidaseN-acetyl cysteinemultidrug resistance-associated proteinLiverCarbon tetrachlorideclofibrateGlutamate–cysteine ligase catalytic subunitInterferon gammaGamma-glutamylcysteine synthetaseGlutathioneglutathione disulfide
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Authors
Daniel W. Ferreira, Michael J. Goedken, Samuel Rommelaere, Lionel Chasson, Franck Galland, Philippe Naquet, José E. Manautou,