High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/Î²-catenin and p38 MAPK

Article ID	Journal	Published Year	Pages	File Type
8259548	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2016	40 Pages	PDF

Keywords

FITC CFSE DM2 PAMPs T-cell factor/lymphoid enhancer factor IL-4 MLR HSPs DCs DCFDA HYG DAMPs JNKs GMCSF LPS FACS PBS 2′,7′-dichlorofluorescein diacetate BSA c-Jun N-terminal kinases ERKs MAPKs p38 MAPK ROS TCF/LEF Wnt/β-Catenin damage associated molecular patterns bovine serum albumin PEL Interleukin 4 cluster differentiation Type 2 diabetes Dendritic cells fluorescein isothiocyanate Primary effusion lymphoma luminol lipopolysaccharide Phosphate-buffered saline Hyperglycemia mixed lymphocyte reaction pathogen associated molecular patterns Heat shock proteins Quercetin mitogen-activated protein kinases high glucose Reactive oxygen species

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High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/Î²-catenin and p38 MAPK

Authors

Maria Saveria Gilardini Montani, Marisa Granato, Laura Cuomo, Sandro Valia, Livia Di Renzo, Gabriella D'Orazi, Alberto Faggioni, Mara Cirone,