Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8259723 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2015 | 9 Pages |
Abstract
These data provide evidence for an adaptive proteinase response in diabetic kidneys, affected by excessive collagen-CML formation and decreased collagen digestibility. The normalisation of collagen and partial normalisation of CML- and CTSL-levels by TETA treatment supports the involvement of Cu(II) in CML formation and altered collagen metabolism in diabetic kidneys. Cu(II)-chelation by TETA may represent a treatment option to rectify collagen metabolism in diabetes independent of alterations in blood glucose levels.
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Authors
Sebastian Brings, Shaoping Zhang, Yee S. Choong, Sebastian Hogl, Martin Middleditch, Meder Kamalov, Margaret A. Brimble, Deming Gong, Garth J.S. Cooper,