Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8259776 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2015 | 12 Pages |
Abstract
Silent information regulator-2 (Sir-2) proteins, or sirtuins, are a highly conserved protein family of histone deacetylases that promote longevity by mediating many of the beneficial effects of calorie restriction which extends life span and reduces the incidence of cancer, cardiovascular disease (CVD), and diabetes. Here, we review the role of sirtuins (SIRT1-7) in vascular homeostasis and diseases by providing an update on the latest knowledge about their roles in endothelial damage and vascular repair mechanisms. Among all sirtuins, in the light of the numerous functions reported on SIRT1 in the vascular system, herein we discuss its roles not only in the control of endothelial cells (EC) functionality but also in other cell types beyond EC, including endothelial progenitor cells (EPC), smooth muscle cells (SMC), and immune cells. Furthermore, we also provide an update on the growing field of compounds under clinical evaluation for the modulation of SIRT1 which, at the state of the art, represents the most promising target for the development of novel drugs against CVD, especially when concomitant with type 2 diabetes.
Keywords
AMPKLKB1NF-κBAICAREPCSMCCSEDDRACEICAM-1HUVECMCP-1eNOSSIRTsirtuinMnSODAT1RPGC-1αNAMPTHIFSirtuinsELAVPCISir2STEMIVCAM-1GHDDDAH2Intensive glycemic controlPPAR-αPDHIGCKDRCaMKKβSIN-1UCPTIMP3NBS1RFX5peroxisome proliferator-activated receptor gamma coactivator 1-alpha3-morpholinosydnonimineAMP-activated protein kinaseataxia telangiectasia mutatedNAD+ROSAdenosine TriphosphateATPangiotensin converting enzymeangiotensin II type 1 receptorAngiotensin IIApoeapolipoprotein Evascular dysfunctionEndotheliumST-segment elevation myocardial infarctionendothelial nitric oxideinterleukinPAIplasminogen activator inhibitorcardiovascular diseaseCOPDChronic obstructive pulmonary diseasesilent information regulator 2tumor necrosis factor-αATMAng IIDimethylarginine dimethylaminohydrolaseembryonic lethal abnormal visionCVDHuman umbilical vein endothelial cellsSmooth muscle cellsEndothelial progenitor cellsEndothelial progenitor cellEndothelial cellsmanganese superoxide dismutasecigarette smoke extractHypoxia-inducible factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)fibroblast growth factor 21TNF-αnuclear factor-kappaBFoxOlow density lipoproteinLDLpercutaneous coronary interventionTissue inhibitor of metalloproteinase 3intercellular adhesion molecule-1vascular cell adhesion molecule-1NAMNitric oxidenicotinamide adenine dinucleotidenicotinamide phosphoribosyltransferaseNicotinamideDNA damage responseUncoupling proteinmonocyte chemoattractant protein-1Single nucleotide polymorphismspyruvate dehydrogenase complexSNPglutamate dehydrogenaseReactive oxygen species
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Ageing
Authors
Nunzia D'Onofrio, Milena Vitiello, Rosario Casale, Luigi Servillo, Alfonso Giovane, Maria Luisa Balestrieri,