| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8259969 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2014 | 9 Pages |
Abstract
The ATP8B1-CDC50A heterodimer is essential for the apical localization of SLC10A2 in Caco-2 cells. Diarrhea in PFIC1/BRIC1 patients has a secretory origin to which SLC10A2 deficiency may contribute. This results in elevated luminal bile salt concentrations and consequent enhanced electrolyte secretion and/or reduced electrolyte resorption.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Vincent A. van der Mark, D. Rudi de Waart, Kam S. Ho-Mok, Merit M. Tabbers, Heleen W. Voogt, Ronald P.J. Oude Elferink, A.S. Knisely, Coen C. Paulusma,