Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8260166 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2014 | 9 Pages |
Abstract
MicroRNAs (miRNAs) are small, noncoding RNAs of 18-22 nucleotides in length that regulate post-transcriptional expression by base-pairing with target mRNAs. It is now clearly established that miRNAs are involved in most of the cell's physiopathological processes (including carcinogenesis and metabolic disorders). This review focuses on miR-223, which was first described as a modulator of hematopoietic lineage differentiation. We outline the role of miR-223 deregulation in several types of cancers and highlight its inclusion in a newly identified and fast-growing family of miRNAs called oncomiRs. We then look at miR-223's emerging role in inflammatory and metabolic disorders, with a particular focus on muscle diseases, type II diabetes, atherosclerosis and vascular calcification. miR-223 is one of the growing number of RNA biomarkers of various human metabolic diseases and is thus of special interest to both researchers and clinicians in the cardiovascular field.
Keywords
CCAAT-enhancer-binding proteinsMMP9MEF2CNLRP3SR-BIE2F1PU.1AAAVSMCMCSFIGF-1RDMDSTMN1Myocyte enhancer factor 2CEGFGATA-binding factor 1IKK-αNF-κBPI3KV-Ki-ras2 Kirsten rat sarcoma viral oncogene homologAMLSDF-1LMO2Fbw7KRASIL-4RANKLC/EBPHCCAbdominal aortic aneurysminterleukin-4miR-223Vascular diseasechronic kidney diseasetumor necrosis factor-αDuchenne muscular dystrophyCancerVascular smooth muscle cellepidermal growth factorE2F transcription factor 1Musclestromal cell-derived factor-1macrophage colony stimulating factorTNF-αNuclear factor-kappa Bphosphoinositide 3-kinasemyoacute myeloid leukemiaMyocardinMicroRNAMiRNACKDGlucose transporter type 4wild-typeHematopoiesisHepatocellular carcinomaGATA-1Glut-4Epidermal growth factor receptor 2Insulin-like growth factor receptorreceptor activator of nuclear factor kappa-B ligandscavenger receptor class B type I
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Authors
Fatiha Taïbi, Valérie Metzinger-Le Meuth, Ziad A. Massy, Laurent Metzinger,