A quinazoline-derivative compound with PARP inhibitory effect suppresses hypertension-induced vascular alterations in spontaneously hypertensive rats

Article ID	Journal	Published Year	Pages	File Type
8260195	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2014	10 Pages	PDF

Abstract

PARP-inhibition has significant vasoprotective effects against hypertension-induced vascular remodeling. Therefore, PARP-1 can be a novel therapeutic drug target for preventing hypertension-induced vascular remodeling in a group of patients, in whom lowering the blood pressure to optimal range is harmful or causes intolerable side effects.

Keywords

NF-κB MAP kinase phosphatase-1 Protein-kinase C Poly(ADP-ribose)polymerase-1 MKP-1 Crm1 ASK1 ANGII PKC AP-1 GSK-3β ASI ERK NADPH DBP DAB SBP PBS 4-HNE Jnk PARP-1 3,3′-diaminobenzidine c-Jun N-terminal kinase MAPK p38 MAPK PI-3 kinase ROS Angiotensin II AIF Par extracellular signal regulated kinase apoptosis inducing factor nuclear factor kappaB Phosphate buffered saline phosphatidylinositide 3-kinase diastolic blood pressure systolic blood pressure chromosome region maintenance 1 nicotinamide adenine dinucleotide phosphate activator protein 1 mitogen-activated protein kinase p38 mitogen-activated protein kinase apoptosis signal-regulating kinase 1 glycogen synthase kinase 3 Reactive oxygen species