Classical NF-ÎºB activation impairs skeletal muscle oxidative phenotype by reducing IKK-Î± expression

Article ID	Journal	Published Year	Pages	File Type
8260479	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2014	11 Pages	PDF

Abstract

Conclusion: Classical NF-ÎºB activation impairs skeletal muscle OXPHEN by reducing IKK-Î± expression. TNF-Î±-induced reductions in muscle IKK-Î± may accelerate muscle OXPHEN deterioration in COPD.

Keywords

HMBS PPAR HBSS FVC GUSB IL-1β TFAM IκBα Hprt PPIA MLC PGC-1 b2m NF-κB ALAS1 MyHC YWHAZ IKK-β COXIV UBC RPL13A ubiquitin C Peptidylprolyl isomerase A (cyclophilin A)IKK-α Tnf-α, Tumour necrosis factor alpha FEV1 PBS NRF DMEM ICAM-1 GFP OXPHOS GAPDH Dulbecco's modified Eagle Medium GAPDH, glyceraldehyde-3-phosphate dehydrogenase PPAR, Peroxisome proliferator-activated receptor TFAM, mitochondrial transcription factor A Adenosine Triphosphate ATP adenoviral standard deviation interleukin 1β Chronic obstructive pulmonary disease COPD forced expiratory volume in one second HAD myosin light chain Myosin heavy chain constitutively active Citrate synthase body mass index BMI forced vital capacity Nuclear respiratory factor Skeletal muscle Actb TNF-α nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha nuclear factor kappa B Oxidative phosphorylation Oxidative metabolism Phosphate-buffered saline Hank's balanced salt solution SEM not significant wild-type hydroxymethylbilane synthase green fluorescent protein

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

Classical NF-ÎºB activation impairs skeletal muscle oxidative phenotype by reducing IKK-Î± expression

Authors

A.H.V. Remels, H.R. Gosker, R.C. Langen, M. Polkey, P. Sliwinski, J. Galdiz, B. van den Borst, N.A. Pansters, A.M.W.J. Schols,