Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8260496 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2014 | 15 Pages |
Abstract
Overall, we demonstrate that by improving microtubule-mediated traffic, we can avoid mitochondrial-induced damage and thus recover cell homeostasis. These results prove that NAP may be a promising therapeutic lead candidate for neurodegenerative diseases that involve axonal transport failure and mitochondrial impairment as hallmarks, like Parkinson's disease and related disorders.
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Authors
A.R. Esteves, I. Gozes, S.M. Cardoso,