Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8260551 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2014 | 14 Pages |
Abstract
Vulnerability of the fetus upon maternal obesity can potentially occur during all developmental phases. We aimed at elaborating longer-term health outcomes of fetal overnutrition during the earliest stages of development. We utilized Naval Medical Research Institute (NMRI) mice to induce pre-conceptional and gestational obesity and followed offspring outcomes in the absence of any postnatal obesogenic influences. Male adult offspring developed overweight, insulin resistance, hyperleptinemia, hyperuricemia and hepatic steatosis; all these features were not observed in females. Instead, they showed impaired fasting glucose and a reduced fat mass and adipocyte size. Influences of the interaction of maternal diet â sex concerned offspring genes involved in fatty liver disease, lipid droplet size regulation and fat mass expansion. These data suggest that a peri-conceptional obesogenic exposure is sufficient to shape offspring gene expression patterns and health outcomes in a sex- and organ-specific manner, indicating varying developmental vulnerabilities between sexes towards metabolic disease in response to maternal overnutrition.
Keywords
DPCCD36FABP4Scd2NAFLDPFAMDABscl2Bcl2NMRIEECVCO2CPT1PNPLA2NEFALEPME1PPIAACLYATP citrate lyaseSex-specificityRERNR1H3PPARASREBF1Malic enzyme 1PPARGSfrp5NR3C1ACACApeptidylprolyl isomerase AROINRLTBARSS.E.M.GTTHFDHOMA-IRVO2B cell leukemia/lymphoma 2HMWAUCPLIN2H&EHomeostatic model assessment of insulin resistanceFatty acidfatty acid synthaseNon-esterified fatty acidMRICETPregnancyBaxbeta-actinProgrammingnon-alcoholic fatty liver diseaseanalysis of varianceANOVAMESTglucose tolerance testMagnetic resonance imagingCarbon dioxide productionHeat productioncomputed tomographystandard error of the meancontrol dietsterol regulatory element binding transcription factor 1ActbOffspringFasnLeptinmalondialdehydeObesityOxygen consumptionarea under the curveregion of interestthiobarbituric acid-reactive substanceshairy and enhancer of split 1naval medical research instituteRespiratory exchange ratioNitrogenHes1hematoxylin–eosinbody weightHigh-molecular-weightparaformaldehydeBCL2-associated X proteinfatty acid binding protein 4Peroxisome proliferator activated receptor alphaperilipin 2Carnitine palmitoyltransferase 1Cideaglucocorticoid receptorPeroxisome proliferator activated receptor gamma
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Authors
M. Dahlhoff, S. Pfister, A. Blutke, J. Rozman, M. Klingenspor, M.J. Deutsch, B. Rathkolb, B. Fink, M. Gimpfl, M. HrabÄ de Angelis, A.A. Roscher, E. Wolf, R. Ensenauer,