| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8260658 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 8 Pages |
Abstract
Activated HSCs have increased ROS-detoxifying capacity compared to quiescent HSCs. Glutathione levels increase during HSC activation and protect against ROS-induced necrosis, whereas hydrogen peroxide-detoxifying enzymes protect against apoptotic cell death.
Keywords
deoxynucleoside triphosphatesGSHGPXHO-1PMSFFCSGCLBSOdNTPGSSGheme-oxygenase-1l-buthionine-sulfoximine3ATN-2-hydroxyethylpiperazine-N-2-ethanesulfonic acidTGF-βGSH-MEEphenylmethanesulphonylfluoridePPAR-γα-SMAHSCPBSHEPES3-amino-1,2,4-triazoleNADPH-oxidaseROSEDTAEthylenediaminetetraacetic acidRNAribonucleic acidmercaptosuccinic acidα-smooth muscle actinTransforming Growth Factor BetaOxidative stressSODfetal calf serumHepatic stellate cellSuper Oxide DismutaseSuperoxide dismutaseglutamate cysteine ligasePhosphate-buffered salineCell deathnicotinamide adenine dinucleotide phosphate-oxidasepolymerase chain reactionPCRCatalasereduced glutathionePeroxisome proliferator-activated receptor gammaoxidized glutathioneglutathione peroxidaseReactive oxygen species
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Authors
Sandra Dunning, Atta ur Rehman, Marjolein H. Tiebosch, Rebekka A. Hannivoort, Floris W. Haijer, Jannes Woudenberg, Fiona A.J. van den Heuvel, Manon Buist-Homan, Klaas Nico Faber, Han Moshage,