| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8260949 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 12 Pages |
Abstract
⺠By definition metastatic cancers do not respond to drug treatments. ⺠Lack of drugs response is associated with over expression of membrane pumps involved in the efflux of drug. ⺠pH efflux is also central to cancer metabolism and metastasis and a connection may exist between drug/pH efflux. ⺠It is membrane biophysical structure that allows the interaction between metabolism and drug resistance in cancer. ⺠The modulation of metastasis requires new therapeutic strategies targeting the membrane of cancer cells.
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Authors
Chloë Daniel, Charlotte Bell, Christopher Burton, Salvador Harguindey, Stephan J. Reshkin, Cyril Rauch,