X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling

Article ID	Journal	Published Year	Pages	File Type
8260961	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2013	11 Pages	PDF

Abstract

âº Mutations of the CUL4B gene are linked to X-linked intellectual disability. âº Jab1 is identified as a specific substrate for CUL4B E3 ligase. âº Accumulated Jab1 in response to CUL4B deficiency enhances BMP signaling.

Keywords

DWD XLID MEF CHX CRLs Jab1 CSN Small interfering RNA ROS siRNA Jamm X-linked intellectual disability Smurf cycloheximide BMP signaling BMP mouse embryonic fibroblasts intellectual disability Bone morphogenetic protein Reactive oxygen species

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Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

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X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling

Authors

Fengjuan He, Defen Lu, Baichun Jiang, Yan Wang, Qiao Liu, Qiji Liu, Changshun Shao, Xi Li, Yaoqin Gong,