Article ID Journal Published Year Pages File Type
8260974 Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013 9 Pages PDF
Abstract
► The liver lymphocyte population is enriched with NK and NKT cells. ► NK cells inhibit liver fibrosis by killing activated HSCs and by producing IFN-γ. ► IFN-α therapy enhances, while alcohol and TGF-β inhibit, NK cell killing of HSCs. ► NKT cells produce pro-fibrotic cytokines to promote liver fibrosis. ► NKT cells also produce anti-fibrotic cytokines to inhibit liver fibrosis.
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