Article ID Journal Published Year Pages File Type
8260983 Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013 14 Pages PDF
Abstract
► PDN affects Cav3.2 and TRPV1 channels in small DRG neurons. ► Hyperalgesic PDN upregulated both Cav3.2 and TRPV1 channels. ► Hypoalgesic PDN downregulated Cav3.2 and TRPV1 channels. ► Upregulation of Cav3.2 and downregulation of TRPV1 channels under normalgesic PDN ► Increased T-type window current contributes to the resting [Ca2 +]i in diabetes.
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