| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8260988 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 10 Pages |
Abstract
⺠BCAAs cross the blood-brain barrier and influence several important brain functions. ⺠They are used as dietary integrators in elderly, neurological patients and athletes. ⺠High BCAAs favour astrocyte-dependent neurotoxicity by NMDA receptor activation. ⺠High BCAAs influence gene expression and immune properties of microglial cells. ⺠High BCAAs may promote low grade chronic inflammation favouring neurodegeneration.
Keywords
MMPUDP15-F2t-isoprostane15-F2t-IsoPTMREBMEKPBSARG-1IGF-1ADPM2 phenotypePFAPBSBCAAsLPSiNOSmTORMSUDArginase-1branched-chain amino acidsinsulin-like growth factor-1interleukinBCAAMaple syrup urine diseasetetramethylrhodamine ethyl ester perchlorateNeurodegenerationtumor necrosis factor-αinducible nitric oxide synthaseTNF-αmicroglial activationlipopolysaccharideBrain macrophagesPhosphate-buffered salinebasal Eagle's mediumNitric oxidemammalian target of rapamycinparaformaldehydeMitochondrial membrane potentialMannose receptor
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Authors
Roberta De Simone, Federica Vissicchio, Cecilia Mingarelli, Chiara De Nuccio, Sergio Visentin, Maria Antonietta Ajmone-Cat, Luisa Minghetti,