| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261034 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 4 Pages |
Abstract
⺠Transketolase-like protein 1 (TKTL1) is a marker of certain tumor tissues. ⺠Site-specific mutagenesis was used for modifying human transketolase (hTKT) gene. ⺠The mutant (DhTKT) had a deletion of 38 amino acid residues in hTKT protein. ⺠This deletion is the major difference between hTKT and TKTL1. ⺠We demonstrate that DhTKT is devoid of transketolase activity and lacks bound ThDP.
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Authors
Ludmilla E. Meshalkina, Valeriy L. Drutsa, Olga N. Koroleva, Olga N. Solovjeva, German A. Kochetov,