Insulin-like growth factor-1 regulates glutathione peroxidase expression and activity in vascular endothelial cells: Implications for atheroprotective actions of insulin-like growth factor-1

Article ID	Journal	Published Year	Pages	File Type
8261035	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2013	9 Pages	PDF

Abstract

âº Potential antioxidant effects of IGF-1 were tested in vascular endothelial cells. âº IGF-1 upregulated GPX activity via a phosphoinositide-3 kinase dependent pathway. âº IGF-1 modulated selenocysteine-incorporation complex formation on GPX1 mRNA. âº IGF-1 blocked oxidant-induced premature senescence in vascular endothelial cells.

Keywords

CHX NG-nitro-d-arginine methyl ester nLDL SECIS SBP2 Nuclear factor erythroid 2-like 2 HAECs NG-nitro-l-arginine methyl ester oxLDL eIF4E eukaryotic initiation factor 4E binding protein 1 4EBP1 IGF-1 PI3K Nrf2 GPX 2′,7′-dichlorodihydrofluorescein diacetate d-NAME H2DCFDA l-NAME ROS Atherosclerosis Apoe apolipoprotein E Endothelial dysfunction Oxidative stress Selenocysteine insertion sequence dihydroethidium human aortic endothelial cells cycloheximide eukaryotic initiation factor 4E insulin-like growth factor 1 phosphatidylinositide 3-kinase Oxidized low-density lipoprotein native low-density lipoprotein Growth hormone DHE Senescence glutathione peroxidase Reactive oxygen species