| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261036 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 11 Pages |
Abstract
⺠DAAO controls the cellular concentration of the neuromodulator d-serine. ⺠Here, three point variants of human DAAO have been investigated. ⺠G331V DAAO yields protein aggregation, augments apoptosis and low cell viability. ⺠D31H and R279A increase DAAO activity and FAD binding and decrease cellular d-serine level. ⺠The latter condition correlates to an increased risk to schizophrenia.
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Authors
Laura Caldinelli, Silvia Sacchi, Gianluca Molla, Marco Nardini, Loredano Pollegioni,