| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261071 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 22 Pages |
Abstract
⺠PSAP was identified as an apoptotic protein and associated with Alzheimer presenilin. ⺠First, we found that induces apoptosis dependent on Smac and Apaf-1; ⺠Second, BAx, tBid, and Bak are not required for PSAP-induced cytochrome c release; ⺠Third, PSAP-induced apoptosis was not protected by Bcl-2 protein. ⺠PSAP opens a new avenue to study the mechanism of mitochondria-mediated apoptosis.
Keywords
second mitochondria-derived activator of caspases/direct IAP binding protein with low PIBcl-2COX-1IAPAPAf-1DISClacZFADDPSAPPARPz-VAD-fmkSmac/DIABLOβ-galactosidasebenzyloxycarbonyl-Val-Ala-Asp-fluoromethylketoneAlzheimer's diseaseOxidative stressFas-associated death domainApoptosisApoptotic protease-activating factor 1B-cell lymphoma 2MitochondriaPoly(ADP-ribose) polymerasedeath-inducing signaling complex
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Ting Li, Linlin Zeng, Wei Gao, Mei-Zhen Cui, Xueqi Fu, Xuemin Xu,