| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261087 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 10 Pages |
Abstract
⺠Inactive cruzipain triggers TLR2 and IL-6 secretion, leading to cardioprotection. ⺠Cruzipain enzymatically cleaves the IL-6 receptor gp130 in different host cells. ⺠This is reverted when the enzyme is complexed with chagasin, a parasite inhibitor. ⺠Cruzipain induces the release of Ig-like domain of gp130 on human leukocytes. ⺠Trypomastigote supernatants abolish STAT3 phosphorylation in splenocytes.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Nicolás Eric Ponce, Eugenio Antonio Carrera-Silva, Andrea Vanina Pellegrini, Silvia Inés Cazorla, Emilio Luis Malchiodi, Ana Paula Lima, Susana Gea, Maria Pilar Aoki,