| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261107 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 9 Pages |
Abstract
⺠Mitochondrial dysfunction is an early event in Alzheimer's disease. ⺠VDAC1 protein levels are elevated in AD brains and cortical tissues from APP transgenic mice. ⺠VDAC1 is interacted with Aβ and phospho tau and disrupts the transport of metabolites. ⺠VDAC1 + Aβ and Aβ + phospho tau complexes cause defects in OXPHOS in AD neurons.
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Authors
P. Hemachandra Reddy,