| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261192 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 9 Pages |
Abstract
⺠Smad6, Smad7 and hepcidin are co-regulated in response to iron via Bmp/Smad-pathway. ⺠Hemochromatosis mouse models show inappropriately low hepcidin, Smad6 and Smad7 levels. ⺠Iron injections activate hepcidin, Smad6 and Smad7 mRNA levels despite the lack of Hfe. ⺠Bmp/Smad-independent signals may convey hepcidin, Smad6 and Smad7 response to iron.
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Authors
Maja VujiÄ SpasiÄ, Richard Sparla, Katarzyna Mleczko-Sanecka, Mary C. Migas, Katja Breitkopf-Heinlein, Steven Dooley, Sophie Vaulont, Robert E. Fleming, Martina U. Muckenthaler,