| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261216 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 9 Pages |
Abstract
⺠Polyglutamine (polyQ) expansion in huntingtin (htt) protein causes Huntington's disease (HD). ⺠PolyQ-htt-induced alteration of EGFR trafficking affects cell migration and proliferation by EGF. ⺠Alteration in EGFR trafficking occcurs, at least in part, through inhibition of ERK signaling.
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Authors
Mariarosa A.B. Melone, Anna Calarco, Orsolina Petillo, Sabrina Margarucci, Luca Colucci-D'Amato, Umberto Galderisi, Guido Koverech, Gianfranco Peluso,