| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261245 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 9 Pages |
Abstract
⺠Human proximal tubule cell line to study renal pharmacokinetics. ⺠Uremic toxins decrease UDP-glucuronosyltransferase activity. ⺠Uremic toxins interact with mitochondria (e.g. mitochondrial succinate dehydrogenase). ⺠Uremic toxins diminish the reserve capacity of the energy-generating OXPHOS system. ⺠Uremic toxins might play an important role in altering drug metabolism in patients with chronic kidney disease.
Keywords
CRFantimycin APHSPHGPcGCMPF3-carboxy-4-methyl-5-propyl-2-furanpropanoic acidFCCPFCSHEK293Oligomycin ANATOXPHOS7-OHCOmyPHACyPGST3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide7-hydroxycoumarinMTTN-acetyltransferaseNAD+p-cresolindole-3-acetic acidPhenylacetic acidHippuric acidkynurenic acidOxalatechronic kidney diseaseOatorganic anion transporterPCsindoxyl sulfatefetal calf serumhuman embryonic kidney cellsCytochrome P450Electron transport systemOxidative phosphorylationmediumMIxChronic renal failureCKDLeaknicotinamide adenine dinucleotidep-cresyl sulfatehigh-performance liquid chromatographyHPLCglutathione S-transferase
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Authors
H.A.M. Mutsaers, M.J.G. Wilmer, D. Reijnders, J. Jansen, P.H.H. van den Broek, M. Forkink, E. Schepers, G. Glorieux, R. Vanholder, L.P. van den Heuvel, J.G. Hoenderop, R. Masereeuw,