| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261259 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 12 Pages |
Abstract
⺠We induce prostate hyperplasia in rats by injecting LPS into prostates. ⺠Cytokines secreted from activated macrophages stimulate the HIF-1 signaling pathway. ⺠HIF-1 drives EMT in prostate epithelial cells. ⺠HIF-1 inhibitors block EMT and hyperplasia in LPS-treated prostates. ⺠This study will open a new concept about the pathogenesis of inflammatory BPH.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Hye-Jin Kim, Jong-Wan Park, Young-Suk Cho, Chung-Hyun Cho, Ji-Seon Kim, Hyun-Woo Shin, Doo Hyun Chung, Sang Jeong Kim, Yang-Sook Chun,