| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261264 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 12 Pages |
Abstract
⺠We demonstrated a role of Sirt3 in the regulation of acetylation and activity of mitochondrial FoF1ATPase. ⺠The OSCP subunit of FoF1ATPase was identified as a new target of Sirt3. ⺠ROS overproduction led to a decline in the expression level of Sirt3 and the impairment of FoF1ATPase. ⺠Oxidative stress is involved in the Sirt3 deficiency in human cells harboring the 4977 bp deletion of mtDNA.
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Authors
Yu-Ting Wu, Hsin-Chen Lee, Chen-Chung Liao, Yau-Huei Wei,