| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8261279 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 | 12 Pages |
Abstract
⺠Glutamate-induced excitotoxicity decreases proteasome activity, particularly in nucleus. ⺠Extrasynaptic NMDA receptors contribute to the downregulation of proteasome activity. ⺠OGD impairs proteasome activity by mechanisms dependent on NMDA receptor activation. ⺠Glutamate-induced excitotoxicity evokes 26S proteasome disassembly. ⺠Proteasome inhibition induces hippocampal neuronal death.
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Authors
Margarida V. Caldeira, Michele Curcio, Graciano Leal, Ivan L. Salazar, Miranda Mele, Ana Rita A. Santos, Carlos V. Melo, Paulo Pereira, Lorella M.T. Canzoniero, Carlos B. Duarte,