Article ID Journal Published Year Pages File Type
8261292 Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013 10 Pages PDF
Abstract
► BCR-Abl interacts with and is a substrate of tyrosine phosphatase, TC48. ► TC48 mediated dephosphorylation of BCR-Abl at Y1127 and Y1294 causes its inactivation. ► c-Abl, or its active variants are not dephosphorylated and inactivated by TC48. ► TC48 expression inhibits growth and enhances STI571 sensitivity of K562 cells.
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Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
The tyrosine phosphatase TC48 interacts with and inactivates the oncogenic fusion protein BCR-Abl but not cellular Abl
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