Downregulation of A1 and A2B adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi

Article ID	Journal	Published Year	Pages	File Type
8261305	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2012	11 Pages	PDF

Abstract

âº Adenosine receptors (ARs) have never been characterized in aneuploid pregnancies. âº Here ARs were investigated in euploid and trisomy 21 chorionic villi and mesenchymal cells. âº Reduced A1 and A2B expression was revealed in aneuploid chorionic villi and mesenchymal cells. âº A1 and A2BARs increasing NO and VEGF secretion may improve fetoplacental perfusion.

Keywords

DPCPX NECA 5′-N-ethylcarboxamidoadenosine Angiogenesis Trisomy 21 Mesenchymal stem cells Mesenchymal cells Chorionic villi Adenosine receptors

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

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Downregulation of A1 and A2B adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi

Authors

Stefania Gessi, Stefania Merighi, Angela Stefanelli, Prisco Mirandola, Alessandra Bonfatti, Sergio Fini, Alberto Sensi, Roberto Marci, Katia Varani, Pier Andrea Borea, Fortunato Vesce,