Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8261305 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 11 Pages |
Abstract
⺠Adenosine receptors (ARs) have never been characterized in aneuploid pregnancies. ⺠Here ARs were investigated in euploid and trisomy 21 chorionic villi and mesenchymal cells. ⺠Reduced A1 and A2B expression was revealed in aneuploid chorionic villi and mesenchymal cells. ⺠A1 and A2BARs increasing NO and VEGF secretion may improve fetoplacental perfusion.
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Authors
Stefania Gessi, Stefania Merighi, Angela Stefanelli, Prisco Mirandola, Alessandra Bonfatti, Sergio Fini, Alberto Sensi, Roberto Marci, Katia Varani, Pier Andrea Borea, Fortunato Vesce,